Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

Across TCGA cell cohorts, RNA activity of the Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFIT3, UNK, and ESRP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules activity versus IFIT3 in BREAST (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	IFIT3 →	+2.053	+0.697	.006	.007	3	5
BLOOD_Lymphoma	UNK →	-0.615	-0.734	.003	.007	3	4
BLOOD_Leukemia	ESRP1 →	-1.403	-0.971	.001	.002	3	4
SOFT_TISSUE	IL15RA →	+2.286	+0.560	<.001	<.001	3	4
OVARY	TNIP1 →	+0.883	+0.283	.006	.005	3	4
BLOOD_Leukemia	TNFSF13B →	+1.883	+0.920	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007157 vs IFIT3 — BREAST

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