Homophilic cell adhesion via plasma membrane adhesion molecules

Across TCGA patient cohorts, RNA activity of the Homophilic cell adhesion via plasma membrane adhesion molecules pathway is significantly associated with the RNA expression of multiple genes, with the UCS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DLG5, PJA2, and AFF4, each associated with the pathway in up to 26 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Homophilic cell adhesion via plasma membrane adhesion molecules activity versus DLG5 in UCS (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	DLG5 →	+2.118	+0.030	<.001	<.001	3	26
THYM	PJA2 →	+1.053	+0.036	<.001	<.001	3	26
THYM	AFF4 →	+1.182	+0.039	<.001	<.001	3	26
THYM	ARHGEF12 →	+1.700	+0.040	<.001	<.001	3	26
THYM	PCDHGC3 →	+2.390	+0.040	<.001	<.001	3	26
MESO	PCDHB12 →	+1.300	+0.029	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007156 vs DLG5 — UCS

Explore this scatter interactively →