Homophilic cell adhesion via plasma membrane adhesion molecules

Across TCGA patient cohorts, RNA activity of the Homophilic cell adhesion via plasma membrane adhesion molecules pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL5A1, SLC6A1, and GJA1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Homophilic cell adhesion via plasma membrane adhesion molecules activity versus COL5A1 in CCRCC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	COL5A1 →	+1.177	+0.462	<.001	.006	3	7
GBM	SLC6A1 →	+0.842	+0.413	<.001	<.001	3	7
LSCC	GJA1 →	+1.431	+0.623	<.001	<.001	3	6
CCRCC	DKK3 →	+0.861	+0.628	<.001	<.001	3	6
CCRCC	IRAG1 →	+1.219	+0.906	<.001	<.001	3	6
LSCC	MMP11 →	+1.580	+0.632	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007156 vs COL5A1 — CCRCC

Explore this scatter interactively →