Homophilic cell adhesion via plasma membrane adhesion molecules

Across TCGA cell cohorts, RNA activity of the Homophilic cell adhesion via plasma membrane adhesion molecules pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASSF4, BTN2A1, and LCORL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RASSF4 grouped by Homophilic cell adhesion via plasma membrane adhesion molecules-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RASSF4 →	-0.698	-0.664	.004	.006	3	5
BREAST	BTN2A1 →	-0.769	-0.613	<.001	.003	3	5
OVARY	LCORL →	-0.648	-0.876	<.001	<.001	3	5
BREAST	RUFY2 →	-0.621	-0.735	<.001	<.001	3	5
BLOOD_Myeloma	CCDC93 →	-1.057	-2.064	.004	<.001	3	4
BLOOD_Myeloma	KIAA1109 →	-1.061	-1.267	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RASSF4 by Homophilic cell adhesion via plasma membrane adhesion molecules activity — BREAST

Explore this box plot interactively →