Homophilic cell adhesion via plasma membrane adhesion molecules

Across TCGA cell cohorts, RNA activity of the Homophilic cell adhesion via plasma membrane adhesion molecules pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PKD2, DDX60L, and SIGMAR1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Homophilic cell adhesion via plasma membrane adhesion molecules activity versus PKD2 in BLOOD_Lymphoma (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PKD2 →	+1.318	+0.359	.004	<.001	3	5
BONE	DDX60L →	+2.006	+0.786	.002	.002	3	5
STOMACH	SIGMAR1 →	-0.813	-0.341	.008	.006	2	6
BONE	PITPNM3 →	+1.467	+0.594	.003	.004	2	6
PANCREAS	TARDBP →	-0.555	-0.397	.001	<.001	3	4
PANCREAS	SAFB →	-0.542	-0.330	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007156 vs PKD2 — BLOOD_Lymphoma

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