Female meiosis I

Across TCGA patient cohorts, RNA activity of the Female meiosis I pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GINS1, CENPI, and DDIAS, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Female meiosis I activity versus GINS1 in LUAD (Pearson r = 0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GINS1 →	+0.940	+0.653	<.001	<.001	3	6
LUAD	CENPI →	+0.970	+0.668	<.001	<.001	3	6
BRCA	DDIAS →	+0.964	+0.639	<.001	.001	3	6
LUAD	NCAPG →	+0.685	+0.447	<.001	<.001	3	6
BRCA	TTK →	+1.416	+0.528	<.001	<.001	3	6
BRCA	CENPA →	+1.241	+0.459	<.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007144 vs GINS1 — LUAD

Explore this scatter interactively →