Female meiosis I

Across TCGA cell cohorts, RNA activity of the Female meiosis I pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LPIN2, KLHL2, and GBX2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LPIN2 grouped by Female meiosis I-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LPIN2 →	-1.563	-0.750	<.001	.008	3	3
BREAST	KLHL2 →	-1.092	-0.760	<.001	.005	3	3
BREAST	GBX2 →	-1.058	-0.729	.001	.007	3	3
BREAST	NABP1 →	-1.611	-0.888	<.001	.001	3	3
BREAST	NSMAF →	-1.071	-0.859	<.001	.002	3	3
BREAST	PRR11 →	-1.712	-0.796	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LPIN2 by Female meiosis I activity — BREAST

Explore this box plot interactively →