Female meiotic nuclear division

Across TCGA cell cohorts, RNA activity of the Female meiotic nuclear division pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFB2, SCFD1, and EXOC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NDUFB2 grouped by Female meiotic nuclear division-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NDUFB2 →	-0.514	-0.212	.004	.004	3	5
LUNG_NSCLC_LUSC	SCFD1 →	+0.897	+0.215	.002	.009	3	4
LARGE_INTESTINE	EXOC1 →	+0.536	+0.184	.007	.004	2	5
OESOPHAGUS	ENPP4 →	+1.870	+0.220	<.001	<.001	3	4
URINARY_TRACT	COX16 →	-0.842	-0.126	.003	.002	3	4
CNS	FAM171A2 →	-1.089	-0.233	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NDUFB2 by Female meiotic nuclear division activity — LARGE_INTESTINE

Explore this box plot interactively →