Female meiotic nuclear division

Across TCGA cell cohorts, RNA activity of the Female meiotic nuclear division pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPI, CD302, and TFR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Female meiotic nuclear division activity versus CENPI in BLOOD_Myeloma (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CENPI →	+1.617	+0.441	.006	<.001	3	5
BLOOD_Leukemia	CD302 →	-2.485	-0.274	<.001	.001	3	5
BLOOD_Leukemia	TFR2 →	-2.651	-0.263	<.001	<.001	3	5
BLOOD_Leukemia	NCAPH →	+0.674	+0.262	<.001	<.001	3	5
BLOOD_Leukemia	DUSP23 →	-4.182	-0.288	<.001	<.001	3	5
BLOOD_Leukemia	YEATS2 →	+0.854	+0.283	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007143 vs CENPI — BLOOD_Myeloma

Explore this scatter interactively →