Homologous chromosome pairing at meiosis

Across TCGA patient cohorts, RNA activity of the Homologous chromosome pairing at meiosis pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PKMYT1, SPC24, and TK1, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Homologous chromosome pairing at meiosis activity versus PKMYT1 in ACC (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	PKMYT1 →	+1.892	+0.044	<.001	<.001	3	31
ACC	SPC24 →	+2.000	+0.038	<.001	<.001	3	31
ACC	TK1 →	+2.241	+0.036	<.001	<.001	3	31
ACC	POLE2 →	+1.073	+0.033	<.001	<.001	3	30
ACC	ASF1B →	+2.261	+0.048	<.001	<.001	3	30
ACC	ZWINT →	+1.826	+0.041	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007129 vs PKMYT1 — ACC

Explore this scatter interactively →