Homologous chromosome pairing at meiosis

Across TCGA patient cohorts, RNA activity of the Homologous chromosome pairing at meiosis pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTK, SKA1, and UBE2V1P13, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Homologous chromosome pairing at meiosis activity versus TTK in UCEC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TTK →	+1.111	+0.577	<.001	<.001	3	6
UCEC	SKA1 →	+0.909	+0.501	<.001	<.001	3	6
UCEC	UBE2V1P13 →	+1.118	+0.364	<.001	.004	3	6
GBM	DEPDC1 →	+1.025	+0.651	<.001	.007	3	6
GBM	ASPM →	+1.382	+0.779	<.001	.001	3	6
UCEC	HMMR →	+0.982	+0.510	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007129 vs TTK — UCEC

Explore this scatter interactively →