Homologous chromosome pairing at meiosis

Across TCGA cell cohorts, RNA activity of the Homologous chromosome pairing at meiosis pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFB1, TRAF4, and RHOU, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TGFB1 grouped by Homologous chromosome pairing at meiosis-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TGFB1 →	+1.110	+1.528	<.001	<.001	3	5
CNS	TRAF4 →	-0.506	-0.779	<.001	.003	3	5
LUNG_NSCLC_LUAD	RHOU →	-1.514	-0.861	<.001	<.001	3	4
BLOOD_Leukemia	CORO2A →	-2.154	-1.017	<.001	.007	3	4
BLOOD_Myeloma	ACSS1 →	-1.556	-1.450	.007	.001	3	4
BREAST	HPRT1 →	+0.588	+0.537	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TGFB1 by Homologous chromosome pairing at meiosis activity — OESOPHAGUS

Explore this box plot interactively →