Homologous chromosome pairing at meiosis

Across TCGA cell cohorts, RNA activity of the Homologous chromosome pairing at meiosis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEKHF1, LARP6, and FEM1C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Homologous chromosome pairing at meiosis activity versus PLEKHF1 in LARGE_INTESTINE (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLEKHF1 →	-1.185	-0.686	<.001	.008	3	4
STOMACH	LARP6 →	-2.822	-0.911	<.001	.002	3	3
BLOOD_Myeloma	FEM1C →	+1.060	+0.275	<.001	.009	3	3
BLOOD_Leukemia	ANXA1 →	-2.648	-0.314	.001	.009	3	3
LARGE_INTESTINE	CLU →	-3.224	-0.704	<.001	.006	3	3
LUNG_SCLC	PUDP →	-1.186	-0.205	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007129 vs PLEKHF1 — LARGE_INTESTINE

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