Regulation of exit from mitosis

Across TCGA patient cohorts, RNA activity of the Regulation of exit from mitosis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANLN, EME1, and DBF4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of exit from mitosis activity versus ANLN in BRCA (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ANLN →	+0.991	+0.515	<.001	<.001	3	5
BRCA	EME1 →	+0.692	+0.641	.001	<.001	3	5
LUAD	DBF4 →	+0.518	+0.213	<.001	.001	3	5
BRCA	CCNE1 →	+1.098	+0.651	<.001	<.001	3	4
BRCA	HJURP →	+0.836	+0.652	<.001	<.001	3	4
BRCA	GGH →	+0.737	+0.589	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007096 vs ANLN — BRCA

Explore this scatter interactively →