Mitotic G2 DNA damage checkpoint signaling

Across TCGA patient cohorts, RNA activity of the Mitotic G2 DNA damage checkpoint signaling pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D31, ATAD2, and CDC25A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic G2 DNA damage checkpoint signaling activity versus TBC1D31 in BRCA (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TBC1D31 →	+0.384	+0.310	<.001	<.001	3	4
BRCA	ATAD2 →	+0.668	+0.260	<.001	.002	3	4
BRCA	CDC25A →	+0.729	+0.322	<.001	.002	3	4
BRCA	CDC6 →	+0.991	+0.343	<.001	.001	3	4
COAD	MIR4285 →	+0.183	+0.943	.004	<.001	3	4
BRCA	OIP5 →	+0.681	+0.481	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007095 vs TBC1D31 — BRCA

Explore this scatter interactively →