Mitotic G2 DNA damage checkpoint signaling

Across TCGA patient cohorts, RNA activity of the Mitotic G2 DNA damage checkpoint signaling pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SETD1B_T381, ATXN7L3B_S92, and MAML3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic G2 DNA damage checkpoint signaling activity versus SETD1B_T381 in GBM (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SETD1B_T381 →	+0.448	+0.787	<.001	<.001	3	3
UCEC	ATXN7L3B_S92 →	+0.508	+0.676	.001	.003	3	3
CCRCC	MAML3 →	-0.534	-0.681	<.001	<.001	3	3
UCEC	FLNA_S2352 →	-0.530	-0.805	.001	<.001	3	3
BRCA	DNMT1 →	+0.405	+0.401	<.001	.004	3	3
GBM	AMBRA1_S639 →	+0.601	+0.804	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007095 vs SETD1B_T381 — GBM

Explore this scatter interactively →