Mitotic G2 DNA damage checkpoint signaling

Across TCGA cell cohorts, RNA activity of the Mitotic G2 DNA damage checkpoint signaling pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CUEDC2, ITGA5, and AGTRAP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic G2 DNA damage checkpoint signaling activity versus CUEDC2 in LIVER (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CUEDC2 →	+1.610	+1.578	.003	.005	3	5
STOMACH	ITGA5 →	+2.555	+1.307	.002	<.001	3	5
LUNG_SCLC	AGTRAP →	+1.465	+1.236	.001	<.001	3	5
LUNG_SCLC	NOLC1 →	+0.657	+0.983	<.001	.002	3	4
OESOPHAGUS	KRT19 →	-4.092	-1.297	<.001	<.001	3	4
LUNG_SCLC	LMBRD2 →	-0.874	-0.973	<.001	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007095 vs CUEDC2 — LIVER

Explore this scatter interactively →