Mitotic cell cycle checkpoint signaling

Across TCGA patient cohorts, RNA activity of the Mitotic cell cycle checkpoint signaling pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NME1, NPC1L1, and FAM72A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic cell cycle checkpoint signaling activity versus NME1 in BRCA (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NME1 →	+1.073	+1.309	.006	.006	3	3
PDAC	NPC1L1 →	-0.814	-0.466	.003	.002	3	3
BRCA	FAM72A →	+0.739	+1.140	.003	.002	3	3
OV	AKAP12 →	-1.765	-1.016	.002	.006	3	2
OV	NT5E →	-1.487	-0.764	<.001	.004	3	2
OV	SCN2B →	-0.928	-0.829	.006	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007093 vs NME1 — BRCA

Explore this scatter interactively →