Mitotic cell cycle checkpoint signaling

Across TCGA cell cohorts, RNA activity of the Mitotic cell cycle checkpoint signaling pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGBL2, CDC16, and PPP1R12C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AGBL2 grouped by Mitotic cell cycle checkpoint signaling-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	AGBL2 →	+0.360	+0.194	.005	.002	3	5
LUNG_SCLC	CDC16 →	+1.063	+0.142	.002	.004	3	4
BREAST	PPP1R12C →	+0.684	+0.124	<.001	.001	3	4
BREAST	IQCD →	+0.691	+0.113	<.001	.004	3	4
BLOOD_Lymphoma	GALC →	+1.639	+0.391	.005	<.001	3	4
SKIN	DOK4 →	+1.271	+0.160	.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AGBL2 by Mitotic cell cycle checkpoint signaling activity — SKIN

Explore this box plot interactively →