Mitotic cell cycle checkpoint signaling

Across TCGA cell cohorts, RNA activity of the Mitotic cell cycle checkpoint signaling pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RGS9, MAST3, and MOGAT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RGS9 grouped by Mitotic cell cycle checkpoint signaling-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RGS9 →	-0.292	-1.337	.004	<.001	3	5
LARGE_INTESTINE	MAST3 →	+0.177	+1.122	.003	<.001	3	4
STOMACH	MOGAT2 →	-0.276	-1.220	.003	<.001	3	4
STOMACH	CACNA1H →	-0.189	-1.361	.001	<.001	3	3
PANCREAS	ALG9 →	-0.252	-1.183	<.001	<.001	3	3
LUNG_SCLC	ZNF670 →	-0.205	-0.838	.008	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RGS9 by Mitotic cell cycle checkpoint signaling activity — PANCREAS

Explore this box plot interactively →