Mitotic cell cycle checkpoint signaling

Across TCGA cell cohorts, RNA activity of the Mitotic cell cycle checkpoint signaling pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM3C, AP4S1, and CRYBG1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic cell cycle checkpoint signaling activity versus FAM3C in SOFT_TISSUE (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FAM3C →	-1.590	-1.152	.008	.001	3	3
STOMACH	AP4S1 →	+1.966	+1.264	.004	<.001	3	3
OESOPHAGUS	CRYBG1 →	-1.648	-1.135	.008	<.001	3	3
OESOPHAGUS	MDFI →	-2.326	-0.882	.006	<.001	3	3
OESOPHAGUS	TAOK3 →	-0.919	-0.794	.009	.001	3	3
LUNG_SCLC	TMEM123 →	+1.138	+1.025	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007093 vs FAM3C — SOFT_TISSUE

Explore this scatter interactively →