Regulation of mitotic nuclear division

Across TCGA patient cohorts, RNA activity of the Regulation of mitotic nuclear division pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM4, TROAP, and SPC25, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitotic nuclear division activity versus MCM4 in GBM (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MCM4 →	+0.863	+1.610	<.001	<.001	3	8
UCEC	TROAP →	+1.435	+0.837	<.001	<.001	3	8
UCEC	SPC25 →	+1.373	+0.732	<.001	.005	3	8
GBM	RRM2 →	+2.105	+2.210	<.001	<.001	3	8
UCEC	CCNA2 →	+1.413	+0.782	<.001	<.001	3	8
UCEC	CENPN →	+0.909	+0.898	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007088 vs MCM4 — GBM

Explore this scatter interactively →