Regulation of mitotic nuclear division

Across TCGA cell cohorts, RNA activity of the Regulation of mitotic nuclear division pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAP1, ZNF616, and PDXP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitotic nuclear division activity versus ADAP1 in PANCREAS (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ADAP1 →	-1.840	-0.188	.006	.001	3	5
BONE	ZNF616 →	+0.788	+0.199	.002	<.001	3	4
LUNG_SCLC	PDXP →	+1.021	+0.209	.005	.001	3	4
KIDNEY	CPNE8 →	-0.948	-0.211	.006	.001	3	4
LUNG_SCLC	RPAIN →	+1.244	+0.259	<.001	.001	3	4
BLOOD_Lymphoma	ANTXR2 →	-2.552	-0.159	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007088 vs ADAP1 — PANCREAS

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