Mitotic metaphase chromosome alignment

Across TCGA patient cohorts, RNA activity of the Mitotic metaphase chromosome alignment pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BORA, NSD2, and FBXO5, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic metaphase chromosome alignment activity versus BORA in THYM (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	BORA →	+1.415	+0.113	<.001	<.001	3	34
THYM	NSD2 →	+1.579	+0.112	<.001	<.001	3	33
THYM	FBXO5 →	+1.757	+0.112	<.001	<.001	3	33
LIHC	CENPL →	+1.083	+0.065	<.001	<.001	3	33
THYM	TBC1D31 →	+1.098	+0.102	<.001	<.001	3	33
DLBC	DBF4B →	+1.132	+0.054	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007080 vs BORA — THYM

Explore this scatter interactively →