Mitotic metaphase chromosome alignment

Across TCGA cell cohorts, RNA activity of the Mitotic metaphase chromosome alignment pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1orf216, SRSF4, and B3GNT3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C1orf216 grouped by Mitotic metaphase chromosome alignment-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	C1orf216 →	-1.215	-0.256	.008	.004	3	5
SKIN	SRSF4 →	-0.578	-0.203	<.001	<.001	3	5
STOMACH	B3GNT3 →	+2.275	+0.184	.006	.001	3	5
URINARY_TRACT	PIAS2 →	-1.077	-0.367	.008	.001	3	4
OVARY	ZMYM4 →	-0.783	-0.205	<.001	<.001	3	4
OVARY	TIMM21 →	-0.750	-0.167	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C1orf216 by Mitotic metaphase chromosome alignment activity — URINARY_TRACT

Explore this box plot interactively →