Mitotic metaphase chromosome alignment

Across TCGA cell cohorts, RNA activity of the Mitotic metaphase chromosome alignment pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ILF3, ZNF24, and THTPA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic metaphase chromosome alignment activity versus ILF3 in BLOOD_Lymphoma (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ILF3 →	+0.840	+0.264	.001	<.001	3	5
LUNG_SCLC	ZNF24 →	+0.906	+0.163	.001	.004	3	5
UPPER_AERODIGESTIVE_TRACT	THTPA →	+0.902	+1.395	.003	.005	3	5
LUNG_SCLC	SRCAP →	+0.548	+0.192	.003	.002	2	6
BLOOD_Leukemia	CTCF →	+0.879	+0.147	<.001	.001	3	5
BLOOD_Leukemia	KIF22 →	+0.824	+0.185	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007080 vs ILF3 — BLOOD_Lymphoma

Explore this scatter interactively →