Mitotic nuclear membrane disassembly

Across TCGA patient cohorts, RNA activity of the Mitotic nuclear membrane disassembly pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CALM2, ITM2C, and XPC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic nuclear membrane disassembly activity versus CALM2 in HNSC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CALM2 →	+0.593	+0.172	.001	<.001	3	4
HNSC	ITM2C →	+0.890	+0.119	.003	.004	3	3
HNSC	XPC →	+0.627	+0.154	.003	<.001	3	3
HNSC	IL34 →	+0.761	+0.127	.001	.004	3	3
LSCC	IER3IP1 →	-0.512	-0.202	.002	.003	3	3
BRCA	ZBTB41 →	-0.884	-0.607	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007077 vs CALM2 — HNSC

Explore this scatter interactively →