Mitotic nuclear membrane disassembly

Across TCGA cell cohorts, RNA activity of the Mitotic nuclear membrane disassembly pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLK1, ACTR5, and HTR1E, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLK1 grouped by Mitotic nuclear membrane disassembly-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLK1 →	-0.716	-0.252	<.001	<.001	3	13
PANCREAS	ACTR5 →	-0.234	-0.278	<.001	.001	3	5
PANCREAS	HTR1E →	+0.223	+0.244	.003	.003	3	4
BREAST	MDM2 →	+0.262	+0.416	.004	.004	3	4
OVARY	SGCB →	-0.191	-0.266	.008	<.001	3	4
SKIN	RPL9 →	+0.097	+0.206	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLK1 by Mitotic nuclear membrane disassembly activity — LARGE_INTESTINE

Explore this box plot interactively →