Mitotic nuclear membrane disassembly

Across TCGA cell cohorts, RNA activity of the Mitotic nuclear membrane disassembly pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP2R1, AKAP10, and SMIM15, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYP2R1 grouped by Mitotic nuclear membrane disassembly-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CYP2R1 →	+1.663	+0.140	.004	.005	3	4
BONE	AKAP10 →	+0.519	+0.240	.008	.005	3	4
BLOOD_Leukemia	SMIM15 →	+1.681	+0.200	<.001	<.001	3	4
BREAST	FAM222B →	-0.569	-0.125	.007	.007	3	4
OVARY	SETD4 →	+0.619	+0.165	.001	.002	3	4
BLOOD_Lymphoma	C15orf40 →	+0.778	+0.369	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYP2R1 by Mitotic nuclear membrane disassembly activity — OESOPHAGUS

Explore this box plot interactively →