Mitotic nuclear membrane disassembly

Across TCGA cell cohorts, RNA activity of the Mitotic nuclear membrane disassembly pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SFXN1, ARHGAP19, and POLR2C, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic nuclear membrane disassembly activity versus SFXN1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SFXN1 →	+1.585	+1.503	.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	ARHGAP19 →	+0.854	+1.248	<.001	.002	3	7
UPPER_AERODIGESTIVE_TRACT	POLR2C →	+0.872	+1.958	.002	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	UBA2 →	+0.715	+1.240	.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	LSM4 →	+0.731	+1.258	.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	SSRP1 →	+1.048	+1.301	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007077 vs SFXN1 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →