Mitotic nuclear membrane disassembly

Across TCGA cell cohorts, RNA activity of the Mitotic nuclear membrane disassembly pathway is significantly associated with the protein abundance of multiple proteins, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CDK1, UBE2K, and DCTN1, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic nuclear membrane disassembly activity versus CDK1 in OVARY (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CDK1 →	+1.801	+1.324	<.001	<.001	3	16
LIVER	UBE2K →	+2.098	+1.966	.007	<.001	3	15
URINARY_TRACT	DCTN1 →	+1.653	+1.829	<.001	<.001	3	15
BONE	WDR77 →	+1.711	+1.258	<.001	<.001	3	14
OVARY	EIF4E →	+1.450	+1.305	<.001	<.001	3	14
PANCREAS	DNAJC9 →	+1.303	+1.153	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007077 vs CDK1 — OVARY

Explore this scatter interactively →