Mitotic chromosome condensation

Across TCGA patient cohorts, RNA activity of the Mitotic chromosome condensation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DLGAP5, AUNIP, and PKMYT1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic chromosome condensation activity versus DLGAP5 in GBM (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DLGAP5 →	+1.652	+0.504	<.001	.001	3	7
BRCA	AUNIP →	+0.808	+0.621	<.001	<.001	3	7
GBM	PKMYT1 →	+0.842	+0.490	<.001	<.001	3	7
UCEC	PIF1 →	+0.847	+0.622	<.001	.001	3	7
GBM	CDCA5 →	+1.341	+0.624	<.001	<.001	3	7
GBM	CHEK1 →	+1.168	+0.557	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007076 vs DLGAP5 — GBM

Explore this scatter interactively →