Mitotic chromosome condensation

Across TCGA cell cohorts, RNA activity of the Mitotic chromosome condensation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAMTS6, RFWD3, and STOML2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADAMTS6 grouped by Mitotic chromosome condensation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ADAMTS6 →	+2.336	+0.163	.001	.001	3	4
OVARY	RFWD3 →	-0.540	-0.177	.004	.002	3	4
LUNG_NSCLC_LUAD	STOML2 →	-0.500	-0.156	.006	.006	3	4
BLOOD_Lymphoma	IER5 →	+1.497	+0.163	.001	.001	3	4
LUNG_NSCLC_LUSC	LACTB →	+1.486	+0.152	.001	.002	3	3
LUNG_NSCLC_LUSC	HOXA6 →	-1.905	-0.227	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADAMTS6 by Mitotic chromosome condensation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →