Mitotic chromosome condensation

Across TCGA cell cohorts, RNA activity of the Mitotic chromosome condensation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX39A, PSIP1, and METTL21A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic chromosome condensation activity versus DDX39A in PANCREAS (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DDX39A →	+0.907	+1.703	.002	<.001	3	7
BREAST	PSIP1 →	+1.064	+0.996	.002	.001	3	7
URINARY_TRACT	METTL21A →	+0.846	+1.444	.003	<.001	3	6
PANCREAS	PRMT3 →	+1.295	+1.742	<.001	<.001	2	7
BREAST	CDT1 →	+0.896	+1.049	<.001	<.001	3	6
PANCREAS	PNO1 →	+0.872	+1.821	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007076 vs DDX39A — PANCREAS

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