Mitotic sister chromatid cohesion

Across TCGA cell cohorts, RNA activity of the Mitotic sister chromatid cohesion pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMC1A, RAD21, and BUB1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SMC1A grouped by Mitotic sister chromatid cohesion-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SMC1A →	-0.464	-0.259	<.001	.001	3	9
KIDNEY	RAD21 →	-0.548	-0.273	<.001	<.001	3	8
KIDNEY	BUB1 →	-0.288	-0.245	.006	.003	3	7
SKIN	SMC3 →	-0.583	-0.448	<.001	<.001	3	5
KIDNEY	PCDHA8 →	+0.166	+0.278	<.001	<.001	3	4
BLOOD_Myeloma	GUCY2D →	+0.373	+0.341	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SMC1A by Mitotic sister chromatid cohesion activity — PANCREAS

Explore this box plot interactively →