Mitotic sister chromatid cohesion

Across TCGA cell cohorts, RNA activity of the Mitotic sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRF1, COL4A6, and ACADVL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IRF1 grouped by Mitotic sister chromatid cohesion-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	IRF1 →	-2.324	-0.296	.005	.005	3	4
LIVER	COL4A6 →	-2.011	-0.449	<.001	.001	3	3
LIVER	ACADVL →	+1.238	+0.379	.005	.004	3	3
LUNG_NSCLC_LUSC	ERAL1 →	-0.946	-0.524	.001	<.001	3	3
LARGE_INTESTINE	SRRM1 →	-0.627	-0.317	.005	.006	2	4
LARGE_INTESTINE	TBX3 →	-1.505	-0.266	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IRF1 by Mitotic sister chromatid cohesion activity — SOFT_TISSUE

Explore this box plot interactively →