Mitotic sister chromatid cohesion

Across TCGA cell cohorts, RNA activity of the Mitotic sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SKP2, KLHDC3, and CNIH2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic sister chromatid cohesion activity versus SKP2 in BLOOD_Leukemia (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SKP2 →	+1.138	+0.444	<.001	.002	3	6
OVARY	KLHDC3 →	+0.653	+0.687	.002	.001	3	4
LUNG_SCLC	CNIH2 →	+1.670	+0.278	<.001	<.001	3	4
OVARY	HRH1 →	-1.147	-0.647	.002	.002	3	4
BLOOD_Myeloma	IVNS1ABP →	+1.001	+0.247	.008	.009	3	4
BLOOD_Leukemia	MYL6B →	+0.883	+0.393	.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007064 vs SKP2 — BLOOD_Leukemia

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