Regulation of sister chromatid cohesion

Across TCGA patient cohorts, RNA activity of the Regulation of sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXCR2, FPR1, and CXCL8, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of sister chromatid cohesion activity versus CXCR2 in LSCC (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CXCR2 →	-0.928	-0.917	<.001	<.001	2	8
GBM	FPR1 →	-1.076	-0.947	<.001	<.001	3	6
UCEC	CXCL8 →	-1.507	-0.730	.004	.006	3	5
GBM	JDP2 →	-0.619	-1.053	<.001	<.001	3	5
LSCC	CXCR1 →	-0.829	-0.648	.001	.002	2	6
GBM	BEST1 →	-0.718	-0.818	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007063 vs CXCR2 — LSCC

Explore this scatter interactively →