Regulation of sister chromatid cohesion

Across TCGA cell cohorts, RNA activity of the Regulation of sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYDE1, POGLUT2, and ARL3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SYDE1 grouped by Regulation of sister chromatid cohesion-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SYDE1 →	-2.037	-0.369	.002	.002	3	5
BLOOD_Leukemia	POGLUT2 →	-2.428	-0.405	<.001	<.001	3	5
STOMACH	ARL3 →	-0.905	-0.345	.001	.005	3	5
STOMACH	CNPY4 →	-1.232	-0.392	.001	.001	3	5
STOMACH	FLYWCH2 →	-0.830	-0.367	<.001	.002	3	5
STOMACH	MIR1915HG →	-1.489	-0.546	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SYDE1 by Regulation of sister chromatid cohesion activity — STOMACH

Explore this box plot interactively →