Regulation of sister chromatid cohesion

Across TCGA cell cohorts, RNA activity of the Regulation of sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MARK2, DSP, and POLR2G, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of sister chromatid cohesion activity versus MARK2 in LUNG_NSCLC_LUAD (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MARK2 →	+0.598	+0.156	.002	.004	3	7
LUNG_NSCLC_LUSC	DSP →	+2.663	+0.322	.001	<.001	3	6
BREAST	POLR2G →	+0.850	+0.229	.003	.005	3	6
BREAST	RBMX →	+0.517	+0.222	<.001	<.001	3	5
BREAST	FEN1 →	+0.938	+0.307	.002	.001	3	5
LUNG_SCLC	PATL1 →	+0.506	+0.136	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007063 vs MARK2 — LUNG_NSCLC_LUAD

Explore this scatter interactively →