Mitotic spindle organization

Across TCGA patient cohorts, RNA activity of the Mitotic spindle organization pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRACD, RAB40AL, and SNX25, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic spindle organization activity versus CRACD in COAD (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CRACD →	+0.814	+0.202	.004	.008	3	2
COAD	RAB40AL →	-0.125	-0.211	.002	.002	3	1
COAD	SNX25 →	-0.821	-0.196	.001	.008	3	1
COAD	ULBP1 →	-0.676	-0.271	.003	.007	3	1
COAD	ZNF391 →	-0.896	-0.273	.002	.001	3	1
COAD	MATN2 →	+1.030	+0.200	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007052 vs CRACD — COAD

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