Mitotic spindle organization

Across TCGA cell cohorts, RNA activity of the Mitotic spindle organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CARHSP1, FXR1, and TRA2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic spindle organization activity versus CARHSP1 in BLOOD_Leukemia (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CARHSP1 →	+1.321	+0.143	<.001	<.001	3	4
SOFT_TISSUE	FXR1 →	+0.806	+0.215	.003	.003	3	4
BLOOD_Leukemia	TRA2B →	+0.594	+0.139	<.001	<.001	3	4
BLOOD_Leukemia	CEP55 →	+1.067	+0.116	<.001	<.001	3	4
BONE	HEG1 →	+3.910	+0.270	<.001	.003	3	4
OESOPHAGUS	TMEM147 →	-0.804	-0.133	.006	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007052 vs CARHSP1 — BLOOD_Leukemia

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