Spindle organization

Across TCGA cell cohorts, RNA activity of the Spindle organization pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APOBEC3G, LGALS1, and FAM214B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, APOBEC3G grouped by Spindle organization-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	APOBEC3G →	+1.932	+0.107	.001	.009	3	5
BREAST	LGALS1 →	+2.397	+0.118	.005	.009	3	5
UPPER_AERODIGESTIVE_TRACT	FAM214B →	+1.788	+0.176	.003	.005	3	5
OESOPHAGUS	PMM1 →	+1.107	+0.189	<.001	.001	3	4
OESOPHAGUS	A4GALT →	+2.091	+0.139	.001	.003	3	4
OESOPHAGUS	TMEM184B →	+0.922	+0.152	.004	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

APOBEC3G by Spindle organization activity — SOFT_TISSUE

Explore this box plot interactively →