Spindle organization

Across TCGA cell cohorts, RNA activity of the Spindle organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPRYD3, NARS1, and MSANTD3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spindle organization activity versus SPRYD3 in BLOOD_Myeloma (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SPRYD3 →	+0.812	+0.132	.003	<.001	3	6
LUNG_SCLC	NARS1 →	-0.619	-0.116	.005	.004	3	5
CNS	MSANTD3 →	+1.086	+0.137	.005	.001	3	5
KIDNEY	HEATR1 →	-0.971	-0.230	.003	.002	3	5
SKIN	TFB2M →	-0.540	-0.107	.002	.005	3	5
STOMACH	CTRL →	-0.629	-0.238	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007051 vs SPRYD3 — BLOOD_Myeloma

Explore this scatter interactively →