Lysosomal lumen acidification

Across TCGA patient cohorts, RNA activity of the Lysosomal lumen acidification pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDIA3, CRELD2, and ZNF563, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lysosomal lumen acidification activity versus PDIA3 in LUAD (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PDIA3 →	+0.378	+0.138	.004	.004	3	3
BRCA	CRELD2 →	+0.429	+0.093	.009	.009	3	3
LUAD	ZNF563 →	-0.463	-0.136	<.001	.001	3	3
LUAD	C2orf91 →	+0.518	+0.156	<.001	<.001	3	3
LUAD	RBMXP2 →	+0.291	+0.129	.003	.008	3	3
CCRCC	ZNF844 →	-0.530	-0.171	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007042 vs PDIA3 — LUAD

Explore this scatter interactively →