Lysosomal lumen acidification

Across TCGA cell cohorts, RNA activity of the Lysosomal lumen acidification pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C16orf91, UBE2I, and ZNF213, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C16orf91 grouped by Lysosomal lumen acidification-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	C16orf91 →	-0.960	-0.283	.004	.005	3	5
LUNG_NSCLC_LUAD	UBE2I →	-0.367	-0.226	.002	.007	3	5
BLOOD_Leukemia	ZNF213 →	-0.728	-0.361	<.001	.001	3	5
BLOOD_Myeloma	UBALD1 →	-1.102	-0.443	.002	.001	3	4
BLOOD_Myeloma	PIGQ →	-1.348	-0.283	<.001	.005	3	4
BLOOD_Myeloma	NUBP2 →	-0.960	-0.341	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C16orf91 by Lysosomal lumen acidification activity — BLOOD_Myeloma

Explore this box plot interactively →