Lysosomal lumen acidification

Across TCGA cell cohorts, RNA activity of the Lysosomal lumen acidification pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6AP1, LAMP2, and ATP6V0C, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lysosomal lumen acidification activity versus ATP6AP1 in URINARY_TRACT (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ATP6AP1 →	+1.194	+0.366	.008	.009	1	10
CNS	LAMP2 →	+1.321	+0.207	.005	.006	3	6
PANCREAS	ATP6V0C →	+0.978	+0.282	<.001	.002	3	6
BLOOD_Leukemia	CREG1 →	+1.431	+0.235	<.001	<.001	3	5
LIVER	SSR4 →	+0.974	+0.388	.002	.001	3	5
SKIN	L3MBTL1 →	+0.781	+0.171	.008	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007042 vs ATP6AP1 — URINARY_TRACT

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