Vacuolar acidification

Across TCGA patient cohorts, RNA activity of the Vacuolar acidification pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF462, PVALB, and PARK7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vacuolar acidification activity versus ZNF462 in BRCA (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZNF462 →	-0.796	-0.193	<.001	<.001	3	4
PDAC	PVALB →	+0.209	+0.153	.005	.001	3	4
PDAC	PARK7 →	+0.245	+0.228	.002	<.001	3	4
GBM	MAG →	+2.639	+0.437	<.001	.002	3	3
BRCA	PHACTR2 →	-0.487	-0.141	.001	.008	3	3
BRCA	TMEM131L →	-0.457	-0.135	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007035 vs ZNF462 — BRCA

Explore this scatter interactively →