Vacuolar acidification

Across TCGA cell cohorts, RNA activity of the Vacuolar acidification pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRX3, POLR3A, and FBXL8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IRX3 grouped by Vacuolar acidification-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	IRX3 →	-1.626	-0.617	.001	.005	3	4
BREAST	POLR3A →	-0.651	-0.265	.009	.002	3	4
KIDNEY	FBXL8 →	-1.152	-0.357	.002	.005	3	4
BLOOD_Leukemia	KLHDC8B →	-1.940	-0.423	.001	.004	3	4
LUNG_NSCLC_LUAD	NCKAP5L →	-1.026	-0.243	<.001	.004	3	4
LUNG_NSCLC_LUAD	LDB1 →	-0.572	-0.240	.004	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IRX3 by Vacuolar acidification activity — OVARY

Explore this box plot interactively →