Vacuolar acidification

Across TCGA cell cohorts, RNA activity of the Vacuolar acidification pathway is significantly associated with the protein abundance of multiple proteins, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATP6AP1, ATP6V0A1, and ATP6AP2, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vacuolar acidification activity versus ATP6AP1 in CNS (Pearson r = 0.64).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ATP6AP1 →	+1.025	+0.344	<.001	<.001	3	14
BONE	ATP6V0A1 →	+1.646	+0.307	<.001	.001	2	14
PANCREAS	ATP6AP2 →	+1.176	+0.332	<.001	<.001	3	12
CNS	LAMP2 →	+1.670	+0.316	<.001	<.001	3	12
PANCREAS	ATP6V0D1 →	+1.271	+0.317	<.001	<.001	3	12
BREAST	BCAP31 →	+1.120	+0.267	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007035 vs ATP6AP1 — CNS

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